Research
The world is changing at a rapid pace. Landscapes are being altered, climate patterns are shifting, and human populations are expanding. Wild species are also harvested - in sustainable and unsustainable fashions - which influence species' ability to respond to such changes. Our NSERC-funded research program aims to use genomic and epigentic markers to understand how these factors effect population dynamics and demography in natural systems. Good basic research often becomes applied and our goal is to provide tools and information that can help conserve biodiversity.
We have also built a framework that uses experimental approaches and [novel] analytical genomic tools to inform forensic applications. This includes a large-scale simulations, time-since-deposition experiments, and work on human cadavers and porcine analogues.
Current projects:
Epigenomics of natural populations. Using genome wide epigenetic markers we are addressing questions related to aging, island biogegraphy, and adaptive responses. Current work focuss on understanding epigenetic links to phenotypic divergence in shrews, black bear, white-tailed deer, and mountain goat. Collaborators: Don Stewart (Acadia University), Joe Northrup (Ontario Ministry of Natural Resources), NSERC Alliance funded.
Population and speciation genomics. We are using a combination of whole genome sequence to investigate the population demographic history and structural variation of Odocoileus spp. (deer) and black bear across their range. We are using genome sequencing, analysis of structural variants, and GRMs to identify candidate genes and estimate heritabilty of key traits. Some work also integrates ancient DNA!
Ornaments and comparative genomics. We are using large phenotyping databases and whole-genome sequence to get at the genetic basis to horns and antlers. We are also applying a comparative genomics approach to identify conserved genomic regions to estimate genetic load, along with trying to link genomic and populations indicators of genetic health.
Forensic genetics. I have an interest in understanding how genetic information can be applied to the law in the broadest sense. We are exploring the forensic utility of different genomic data sets via simulation. Theresa Stotesbury and I are developing approaches to age bloodstains using DNA / RNA degradation and changes in colour. Since 2022 we have working with Dr. Shari Forbes and the REST[ES] facilty to apply these methods to human tissue (NSERC Discovery Horizons supported).
